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NFL Week 10 Guide: Matchup Previews, Predictions, and Key Insights

The NFL’s Week 10 schedule for the 2025 season features notable matchups and key storylines. Among them, the Atlanta Falcons will face off against the Indianapolis Colts in Germany. Meanwhile, the Detroit Lions seek redemption as they host the Washington Commanders, who eliminated them in the 2024 playoffs.

Key Matchups and Predictions

This week is filled with intriguing matchups between prominent quarterbacks. Drake Maye of the New England Patriots will face Baker Mayfield of the Tampa Bay Buccaneers, while the Ravens will take on the Vikings in a game where Baltimore’s Mark Andrews aims to set a franchise receiving record.

International Spotlight: Falcons vs. Colts

  • Location: Berlin, Germany
  • Kickoff: Sunday at 9:30 a.m. ET
  • Key Players:
    • Jonathan Taylor (Colts)
    • Michael Penix Jr. (Falcons)

The Falcons boast one of the best defenses this season but struggle against the run. The Colts will deploy newly acquired cornerback Sauce Gardner, which may prove pivotal in defending against Atlanta’s top receiver, Drake London.

Ravens vs. Vikings

  • Kickoff: Sunday at 1 p.m. ET
  • Key Player: Mark Andrews (Ravens) needs 18 receiving yards to become the franchise leader.

The Ravens have been solid defensively, allowing only one passing touchdown in their last three games. The Vikings will look to counter this with strategic adjustments from defensive coordinator Brian Flores.

Buffalo Bills vs. Miami Dolphins

  • Kickoff: Sunday at 1 p.m. ET
  • Key Player: Josh Allen (Bills) has an impressive 32.5 points per game average against Miami.

With tensions high, the Dolphins quarterback Tua Tagovailoa acknowledges he must elevate his level of play as he battles against a strong Bills defense.

Detroit Lions vs. Washington Commanders

  • Kickoff: Sunday at 4:25 p.m. ET

After a shocking playoff loss to Washington, the Lions are eager to showcase their offensive capabilities. Key players include Jared Goff, Amon-Ra St. Brown, and Jameson Williams.

Monday Night Football: Philadelphia Eagles vs. Green Bay Packers

  • Kickoff: Monday at 8:15 p.m. ET

This matchup marks a significant test for the Eagles, who have recorded the fewest turnovers in the league. They must find a way to stifle Packers QB Jordan Love, who has been effective against the blitz.

Additional Highlights

  • Injury Updates: Several key players, such as Falcons defensive players and Patriots receivers, have uncertain statuses.
  • Betting Insights: The Colts are currently favored by 6.5 points against the Falcons.
  • Fantasy Football Nuggets: Monitor the performances of Drake Maye and Jonathan Taylor, both expected to play pivotal roles.

This Week 10 lineup promises a mix of returning franchises and fresh rivalries, making for an exciting slate of games as teams jockey for playoff position in their respective divisions.

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