The NFL picks for Week 5 of the 2025 season show an intriguing competition between analysts Florio and Simms. With a growing interest in these predictions, fans are eager to see how the games unfold. Six of the 14 matchups present differing predictions between the two analysts, promising an exciting week ahead.
Current Standings and Predictions
- Florio: 47 wins, 16 losses, 1 tie straight up; 38 wins, 26 losses against the spread.
- Simms: 41 wins, 23 losses, 1 tie straight up; 30 wins, 34 losses against the spread.
Last week, Simms led with 12 wins against 3 losses and 1 tie straight up, while Florio had 11 wins, 4 losses, and 1 tie. Against the spread, Florio performed slightly better, winning 12 to Simms’s 11.
Key Matchups for Week 5
- 49ers at Rams (-8.5): Both teams boast a 3-1 record. Florio and Simms predict a Rams victory with a score of 27-17.
- Vikings (-4.5) vs. Browns in London: Florio expects the Vikings to edge a victory 20-10 against the Browns. Meanwhile, Simms feels the Browns might win 20-17.
- Texans (-1.5) at Ravens: A battle of pride for the Ravens, with Florio predicting a close win at 19-13, while Simms anticipates a Texans win at 27-13.
- Dolphins (-1.5) at Panthers: Without Tyreek Hill, the Dolphins may struggle. Florio predicts a Panthers win, 24-17, while Simms sees a closer game at 24-20.
- Raiders at Colts (-6.5): The Colts continue to impress, and Florio predicts a 30-20 victory. Simms agrees with a slight variation at 31-20.
- Giants at Saints (-1.5): Following a boost from Jaxson Dart, Florio sees the Giants winning 24-20, while Simms thinks the Saints will take it 19-17.
- Cowboys (-2.5) at Jets: In an away game, the Cowboys face a challenge. Florio sees the Jets narrowly winning 34-31, while Simms favors the Cowboys by 28-27.
- Broncos at Eagles (-3.5): Florio expects the Eagles to find a way to win 24-21, whereas Simms thinks the Broncos will take it 23-20.
- Titans at Cardinals (-7.5): Florio predicts a solid Cardinals victory at 30-13, and Simms aligns with a 24-13 prediction.
- Buccaneers at Seahawks (-3.5): Florio believes the Seahawks will win 27-24. Simms is slightly more optimistic, predicting a 30-21 win for Seattle.
- Lions (-10.5) at Bengals: With the Lions trending upward, Florio predicts a 42-14 victory, while Simms expects a closer match at 41-17.
- Commanders at Chargers (-2.5): Florio sees the Chargers winning 28-20, with Simms suggesting a 31-21 finish.
- Patriots at Bills (-8.5): Despite the Bills’ inconsistent performances, Florio picks them to win 30-23, while Simms thinks the Patriots will turn the tables at 27-24.
- Chiefs (-3.5) at Jaguars: The Chiefs are seen as favorites with a 28-20 prediction from Florio and a slightly lower 24-21 estimate from Simms.
As Week 5 progresses, these expert predictions continue to shape the narrative of the NFL season. With bets expected and excitement building, fans will closely monitor the outcomes.
