Clemson vs. Louisville: Expert 2025 Week 12 College Football Predictions

The Louisville Cardinals, currently ranked 15th, are gearing up to face the Clemson Tigers in a crucial Atlantic Coast Conference (ACC) football clash. This matchup is pivotal for Louisville as they strive to maintain their hopes for a conference championship.
Clemson vs. Louisville: Key Matchup Details
Set to kick off at 7:30 p.m. ET, the game will take place at L&N Federal Credit Union Stadium in Louisville, Kentucky. Louisville enters this game with a record of 7-2, including 4-2 in the ACC. Meanwhile, Clemson holds a record of 4-5 and is currently 3-4 in the conference.
Recent Performances
- Clemson won their last game against Florida State with a score of 24-10.
- Louisville is coming off a narrow loss to California, finishing 29-26.
Series History and Betting Lines
Historically, Clemson leads the all-time series against Louisville with a record of 8-1. However, Louisville has recently gained the upper hand by winning the last meeting 33-21. The latest odds indicate that Louisville is a 1.5-point favorite, with the over/under set at 50.5 points.
Betting Insights from SportsLine
Before placing bets on the Clemson vs. Louisville matchup, it is advisable to consult expert predictions and analyses. The SportsLine Projection Model simulates every FBS game 10,000 times, providing insights that have historically generated significant profits. Notably, the model is leaning towards the total points going over 50.5, suggesting that a high-scoring game may be on the horizon. Additionally, the model shows that one side of the spread has a success rate exceeding 50%.
This clash between the Tigers and Cardinals promises to be an exciting encounter, as both teams vie for crucial victories in the ACC standings.



