Game-by-Game Analysis and Predictions: Scores and Matchups

The Tennessee Titans are struggling in the 2025 NFL season, currently holding the worst point differential in the league at -96. This dire situation has resulted in the firing of head coach after just six weeks into his second season. Despite these challenges, defensive tackle Jeffery Simmons has emerged as a standout player for the team.
Jeffery Simmons’ Impressive Performance
Simmons has been a bright spot for the Titans. In the first six weeks, he led all interior defensive linemen with 320 snaps, according to Next Gen Stats. His performance included:
- 4.5 sacks
- 23 quarterback pressures
- 28 tackles
- 23 stops
While Simmons has shone individually, the Titans have struggled collectively, especially after their recent loss to the New England Patriots. Simmons suffered a hamstring injury during that game, which saw the Titans initially leading 10-3 before falling to the Patriots, 31-13.
Impact of Simmons’ Injury
With Simmons sidelined, interim head coach Mike McCoy has categorized his status as “week to week.” This likely means he will miss the upcoming game against the Indianapolis Colts, who are currently enjoying a successful season.
Looking Ahead: Titans vs. Colts Matchup
The Indianapolis Colts have the best point differential in the NFL at +92. Earlier this season, they defeated the Titans decisively, winning by three touchdowns in Nashville. This time, the game will take place at Lucas Oil Stadium, which bodes well for the Colts.
The absence of Simmons may further hinder the Titans’ performance, providing an opportunity for Colts running back Jonathan Taylor to enhance his MVP candidacy. Expectations are high for the Colts as they prepare to face a weakened Titans squad. This matchup promises to be a pivotal moment in the season for both teams.



