The NFL Week 7 matchup features the Indianapolis Colts visiting the Los Angeles Chargers. This game occurs on Sunday, October 19, 2025, at SoFi Stadium, with kickoff set for 4:05 p.m. ET. The Colts enter with a strong record of 5-1, whereas the Chargers are at 4-2. The Chargers are favored by 2.5 points, with the Over/Under set at 48.5 points.
Colts vs Chargers Predictions
As the Colts aim to bounce back from their only loss of the season, all eyes will be on running back Jonathan Taylor. Taylor leads the NFL in rushing yards with 603 yards, averaging 100.5 yards per game. His impressive performance includes an average of 5.2 yards per carry, with 135 total touches this season.
Key Matchup: Taylor vs Chargers Defense
- The Chargers rank 21st in run defense, allowing 124.2 yards per game.
- They struggle against runs in lighter box formations and from shotgun plays.
- In contrast, the Colts rank high in offensive performance against these defensive setups.
Taylor has been exceptionally elusive, forcing 41 missed tackles, leading to 239 yards gained after contact. The Chargers’ defense has also allowed the second-most yardage after missed tackles this season.
Betting Insights
For bettors, a key wager includes Jonathan Taylor hitting the Over on 87.5 rushing yards. Given the Chargers’ vulnerabilities, this bet holds significant promise. Additionally, Taylor’s potential for multiple touchdowns makes 2+ touchdown bets appealing.
Game Predictions
- Moneyline: Colts are favored to win and avenge their earlier loss to the Chargers.
- Spread: The Chargers have struggled to cover the spread recently, failing in their last four games.
- Over/Under: Betting trends indicate that the Over may be a smart choice, with substantial money backing this option.
Injury Updates
The Chargers’ roster is dealing with injuries that could impact their performance, particularly on the offensive line, which is vital when defending against a strong Colts pass rush.
How to Watch the Game
The Colts vs. Chargers game will be broadcasted on CBS. Fans looking to tune in should monitor any updates regarding the weather conditions that could affect the game strategy.
In summary, NFL Week 7 showcases an intriguing matchup between the Colts and Chargers. Key players like Jonathan Taylor will be instrumental in determining the outcome. Bettors should take note of the trends surrounding this exciting contest.
