Week 9 Predictions: Major Upsets in 2025 College Football Season

The 2025 college football season is entering Week 9, and fans are eager to see potential upsets. This week’s predictions highlight five matchups that could surprise bettors. Following a successful previous week, where UConn, BYU, and Georgia Tech delivered profits, the spotlight shifts to new opportunities.
Week 9 Predictions: Major Upsets in 2025 College Football Season
Here are the anticipated upsets for Week 9:
Purdue Boilermakers vs. Rutgers Scarlet Knights
Purdue faces Rutgers as a home underdog after a disappointing loss to Northwestern. Despite getting outgained in yardage, Purdue’s turnovers played a significant role in that defeat. The Boilermakers are expected to bounce back.
- Betting Odds: Purdue +115 on BetMGM
Wake Forest Demon Deacons vs. SMU Mustangs
This matchup could mark the end of SMU’s unbeaten ACC run. Coach Jake Dickert’s teams have performed well as underdogs, including a recent victory over Virginia Tech. Wake Forest’s strong defense may have the upper hand against SMU’s offense.
- Betting Odds: Wake Forest +155 on BetMGM
Kansas State Wildcats vs. Kansas Jayhawks
Kansas State, with a 3-4 record, looks to secure a win to keep its bowl hopes alive. Historically, K-State has dominated this rivalry, winning 16 straight against Kansas. The Wildcats are well-positioned, especially given KU’s defensive struggles.
- Betting Odds: Kansas State +130 on DraftKings
New Mexico State Aggies vs. Missouri State Bears
New Mexico State enters this game as a slight underdog. Quarterback Logan Fife has shown promise, leading Conference USA with a significant throw rate. Meanwhile, Missouri State might be without its starting quarterback due to injury.
- Betting Odds: New Mexico State +100 on bet365
Colorado State Rams vs. Wyoming Cowboys
Colorado State begins its interim coach era with Tyson Summers, aiming for a turnaround after a lackluster season. Wyoming’s recent offensive performance raises concerns as they struggled against weaker opponents. This game could mark a pivotal moment for the Rams.
- Betting Odds: Colorado State +185 on BetMGM
These Week 9 predictions could shake up the standings. As the college football landscape shifts, bettors should keep a close eye on these possible upsets. All odds mentioned reflect current betting markets, and changes may occur as game day approaches.