NFL Week 8 Predictions: Expert Picks for All 13 Game Matchups

As the NFL enters Week 8 of the 2025 season, intriguing matchups are set to unfold, impacting teams’ fortunes. Currently, two teams stand out with impressive records: the 6-1 Indianapolis Colts and the 4-1-1 Green Bay Packers.
NFL Week 8 Predictions
Indianapolis Colts vs. Tennessee Titans
The Indianapolis Colts, led by Daniel Jones, have achieved remarkable success, standing as the top-scoring team in the league with 33.1 points per game. They also rank second in total yards, averaging 380.3 per game. This week, they are favored to face the struggling 1-6 Tennessee Titans, following a significant 31-13 defeat to the New England Patriots.
With a 14.5-point spread, the Colts are the biggest favorites this week. The over/under for this matchup is set at 47.5 points. A victory would bring the Colts’ record to 7-1, solidifying their position for home-field advantage in the upcoming playoffs.
Notable Week 8 Matchups
This week’s schedule features 13 games that will greatly influence teams’ trajectories. SportsLine expert Eric Cohen has provided detailed predictions for these matchups. Cohen boasts a solid record of 70-37-1 (65%) in 2025, following a successful 190-95 record (69%) in the previous year.
- Eagles vs. Giants: Cohen predicts the Eagles (-7) will triumph over the Giants, with a total score of 28 to 18. The Giants’ previous performance raised eyebrows, particularly their last-quarter collapse against Denver.
- High-Scoring Games: Cohen anticipates a high-scoring thriller in one of the matchups, projecting a total of 58 points. Specific details are vital for betting decisions.
Conclusion
As Week 8 unfolds, the outcomes will be critical for several teams. Bettors should consider Cohen’s insights before making any predictions. This week promises to be pivotal in shaping the playoff landscape.