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Houston vs Oklahoma State: Predictions, Picks & Odds for College Football Week 7

The Houston Cougars prepare to face the Oklahoma State Cowboys in a crucial college football matchup on Saturday, October 11, 2025. Both teams are on opposite trajectories; Houston looks to bounce back after their first loss, while Oklahoma State struggles with a four-game losing streak and changes in coaching staff.

Game Overview: Houston vs. Oklahoma State

This Big 12 showdown occurs at Boone Pickens Stadium in Stillwater, Oklahoma. Kickoff is scheduled for 12:00 p.m. ET, with coverage available on TNT.

Current Team Status

  • Houston Cougars: Currently averaging 27.2 points per game, they are looking to regain their winning form.
  • Oklahoma State Cowboys: They’ve struggled offensively, averaging just 16.4 points per game, and rank poorly in both total and passing yards allowed.

Key Player Updates

Houston’s quarterback, Conner Weigman, is a significant question mark for this game. He left the last match against Texas Tech due to a concussion. Before his injury, Weigman had thrown for 93 yards and one touchdown.

On the other hand, Oklahoma State’s quarterback, Zane Flores, is out with a shoulder injury, leaving the team relying on freshman Banks Bowen and former wide receiver Sam Jackson.

Betting Predictions and Odds

The oddsmakers favor Houston in this matchup. The best bet currently stands at:

  • Spread: Houston -14.5 (-110)
  • Moneyline: Houston -620 | Oklahoma State +460
  • Over/Under: Under 46.5 points (-115)

Game Strategy

For Houston to succeed, they will aim to build an early lead. Historically, they have performed well in the first quarter, which could give them a significant advantage. Conversely, Oklahoma State has only managed to stay competitive in a few of their recent losses.

Recent Trends

Oklahoma State has struggled against the spread, failing to cover in nine of their last ten outings. This ongoing trend could play a crucial role in how bettors approach this game.

Conclusion

As both teams prepare for this critical event, Houston appears well-positioned to claim a victory over Oklahoma State. With key player injuries and a struggling offense for the Cowboys, the Cougars could dominate the field.

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